Optoactivation of Locus Ceruleus Neurons Evokes Bidirectional Changes in Thermal Nociception in Rats

Pontospinal noradrenergic neurons are thought to form part of a descending endogenous analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic targeting, we tested the hypothesis that excitation of the locus ceruleus (LC) is antinociceptive. We transduced rat LC ne...

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Auteurs principaux: Hickey, Louise, Li, Yong, Fyson, Sarah J., Watson, Thomas C., Perrins, Ray, Hewinson, James, Teschemacher, Anja G., Furue, Hidemasa, Lumb, Bridget M., Pickering, Anthony E.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960461/
https://ncbi.nlm.nih.gov/pubmed/24647936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4835-13.2014
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