Optoactivation of Locus Ceruleus Neurons Evokes Bidirectional Changes in Thermal Nociception in Rats

Pontospinal noradrenergic neurons are thought to form part of a descending endogenous analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic targeting, we tested the hypothesis that excitation of the locus ceruleus (LC) is antinociceptive. We transduced rat LC ne...

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Autors principals: Hickey, Louise, Li, Yong, Fyson, Sarah J., Watson, Thomas C., Perrins, Ray, Hewinson, James, Teschemacher, Anja G., Furue, Hidemasa, Lumb, Bridget M., Pickering, Anthony E.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960461/
https://ncbi.nlm.nih.gov/pubmed/24647936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4835-13.2014
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