Conditional Knockout of the RNA-Binding Protein HuR in CD4(+) T Cells Reveals a Gene Dosage Effect on Cytokine Production

The posttranscriptional mechanisms by which RNA binding proteins (RBPs) regulate T-cell differentiation and cytokine production in vivo remain unclear. The RBP HuR binds to labile mRNAs, usually leading to increases in mRNA stability and/or translation. Previous work demonstrated that HuR binds to t...

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Detalhes bibliográficos
Main Authors: Gubin, Matthew M, Techasintana, Patsharaporn, Magee, Joseph D, Dahm, Garrett M, Calaluce, Robert, Martindale, Jennifer L, Whitney, Maryln S, Franklin, Craig L, Besch-Williford, Cindy, Hollingsworth, John W, Abdelmohsen, Kotb, Gorospe, Myriam, Atasoy, Ulus
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960399/
https://ncbi.nlm.nih.gov/pubmed/24477678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2013.00127
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