Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress

Head and neck squamous cell carcinoma (HNSCC) is an important endemic disease in Taiwan with aggressive course and dismal outcome. Dasatinib is a Bcr-bl and Src kinase inhibitor that has potential against HNSCC. We recently disclosed that EGFR degradation is critical for dasatinib-induced apoptosis....

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Bibliographische Detailangaben
Hauptverfasser: Lin, Yu-Chin, Wu, Meng-Hsuan, Wei, Tzu-Tang, Lin, Yun-Chieh, Huang, Wen-Chih, Huang, Liang-Yu, Lin, Yi-Ting, Chen, Ching-Chow
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960210/
https://ncbi.nlm.nih.gov/pubmed/24457597
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