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Human mitochondrial DNA: roles of inherited and somatic mutations

Mutations in the human mitochondrial genome are known to cause an array of diverse disorders, most of which are maternally inherited, and all of which are associated with defects in oxidative energy metabolism. It is now emerging that somatic mutations in mitochondrial DNA (mtDNA) are also linked to...

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Detalhes bibliográficos
Main Authors: Schon, Eric A., DiMauro, Salvatore, Hirano, Michio
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959762/
https://ncbi.nlm.nih.gov/pubmed/23154810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3275
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