Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects

Cyclin-dependent kinase 5 (Cdk5) is essential for the proper development of the CNS, as is evident from the perinatal lethality of conventional Cdk5 knockout (Cdk5-/-) mice. Cdk5 is also implicated in numerous complex functions of the adult CNS such as synaptic transmission, synaptic plasticity, and...

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Detalhes bibliográficos
Main Authors: Hirasawa, Motoyuki, Ohshima, Toshio, Takahashi, Satoru, Longenecker, Glenn, Honjo, Yasuyuki, Veeranna, Pant, Harish C., Mikoshiba, Katsuhiko, Brady, Roscoe O., Kulkarni, Ashok B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC395955/
https://ncbi.nlm.nih.gov/pubmed/15067135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307322101
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