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Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact

CD22, a negative regulator of B cell signaling, is a member of the siglec family that binds to α2-6-linked sialic acids on glycoproteins. Previous reports demonstrated that binding of multivalent sialoside probes to CD22 is blocked, or “masked,” by endogenous (cis) ligands, unless they are first des...

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Detalles Bibliográficos
Main Authors: Collins, Brian E., Blixt, Ola, DeSieno, Alexis R., Bovin, Nicolai, Marth, Jamey D., Paulson, James C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC395930/
https://ncbi.nlm.nih.gov/pubmed/15079087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400851101
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