Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA

PURPOSE: Tumor genotyping using cell free plasma DNA (cfDNA) has the potential to allow noninvasive assessment of tumor biology, yet many existing assays are cumbersome and vulnerable to false positive results. We sought to determine whether droplet digital PCR (ddPCR) of cfDNA would allow highly sp...

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Hauptverfasser: Oxnard, Geoffrey R., Paweletz, Cloud P., Kuang, Yanan, Mach, Stacy L., O'Connell, Allison, Messineo, Melissa M., Luke, Jason J., Butaney, Mohit, Kirschmeier, Paul, Jackman, David M., Jänne, Pasi A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959249/
https://ncbi.nlm.nih.gov/pubmed/24429876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2482
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