Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma

Glioblastoma (GBM) is the most common and aggressive histologic subtype of brain cancer with poor outcomes and limited treatment options. Here we report the selective overexpression of the protein arginine methyltransferase PRMT5 as a novel candidate theranostic target in this disease. PRMT5 silence...

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Main Authors: Yan, Fengting, Alinari, Lapo, Lustberg, Mark E., Martin, Ludmila Katherine, Cordero-Nieves, Hector M., Banasavadi-Siddegowda, Yeshavanth, Virk, Selene, Barnholtz-Sloan, Jill, Bell, Erica Hlavin, Wojton, Jeffrey, Jacob, Naduparambil K., Chakravarti, Arnab, Nowicki, Michal O., Wu, Xin, Lapalombella, Rosa, Datta, Jharna, Yu, Bo, Gordon, Kate, Haseley, Amy, Patton, John T., Smith, Porsha L., Ryu, John, Zhang, Xiaoli, Mo, Xiaokui, Marcucci, Guido, Nuovo, Gerard, Kwon, Chang-Hyuk, Byrd, John C., Chiocca, E. Antonio, Li, Chenglong, Sif, Said, Jacob, Samson, Lawler, Sean, Kaur, Balveen, Baiocchi, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959215/
https://ncbi.nlm.nih.gov/pubmed/24453002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0884
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