Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Haem oxygenase (HO)-1/carbon monoxide (CO) protects cancer cells from oxidative stress, but the gas-responsive signalling mechanisms remain unknown. Here we show using metabolomics that CO-sensitive methylation of PFKFB3, an enzyme producing fructose 2,6-bisphosphate (F-2,6-BP), serves as a switch t...

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Detalhes bibliográficos
Main Authors: Yamamoto, Takehiro, Takano, Naoharu, Ishiwata, Kyoko, Ohmura, Mitsuyo, Nagahata, Yoshiko, Matsuura, Tomomi, Kamata, Aki, Sakamoto, Kyoko, Nakanishi, Tsuyoshi, Kubo, Akiko, Hishiki, Takako, Suematsu, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959213/
https://ncbi.nlm.nih.gov/pubmed/24633012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4480
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