Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia

Although therapeutic hypothermia is known to improve neurologic outcomes after perinatal cerebral hypoxia-ischemia, etiology remains unknown. To decipher the mechanisms whereby hypothermia regulates metabolic dynamics in different brain regions, we used a two-step approach: a metabolomics to target...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Takenouchi, Toshiki, Sugiura, Yuki, Morikawa, Takayuki, Nakanishi, Tsuyoshi, Nagahata, Yoshiko, Sugioka, Tadao, Honda, Kurara, Kubo, Akiko, Hishiki, Takako, Matsuura, Tomomi, Hoshino, Takao, Takahashi, Takao, Suematsu, Makoto, Kajimura, Mayumi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420853/
https://ncbi.nlm.nih.gov/pubmed/25586144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.253
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