The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling

The effects of high-fat diet (HFD) and postprandial endotoxemia on the development of type 2 diabetes are not fully understood. Here we show that the serine protease prostasin (PRSS8) regulates hepatic insulin sensitivity by modulating Toll-like receptor 4 (TLR4)-mediated signalling. HFD triggers th...

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Detalhes bibliográficos
Main Authors: Uchimura, Kohei, Hayata, Manabu, Mizumoto, Teruhiko, Miyasato, Yoshikazu, Kakizoe, Yutaka, Morinaga, Jun, Onoue, Tomoaki, Yamazoe, Rika, Ueda, Miki, Adachi, Masataka, Miyoshi, Taku, Shiraishi, Naoki, Ogawa, Wataru, Fukuda, Kazuki, Kondo, Tatsuya, Matsumura, Takeshi, Araki, Eiichi, Tomita, Kimio, Kitamura, Kenichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959208/
https://ncbi.nlm.nih.gov/pubmed/24614850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4428
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