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Power of Family-Based Association Designs To Detect Rare Variants in Large Pedigrees Using Imputed Genotypes

Recently, the “Common Disease-Multiple Rare Variants” hypothesis has received much attention, especially with current availability of next generation sequencing. Family-based designs are well suited for discovery of rare variants, with large and carefully selected pedigrees enriching for multiple co...

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Detalhes bibliográficos
Main Authors: Saad, Mohamad, Wijsman, Ellen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959172/
https://ncbi.nlm.nih.gov/pubmed/24243664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21776
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