Mesenchymal Stem Cells Do Not Prevent Antibody Responses against Human α-L-Iduronidase when Used to Treat Mucopolysaccharidosis Type I

Mucopolysaccharidosis type I (MPSI) is an autosomal recessive disease that leads to systemic lysosomal storage, which is caused by the absence of α-L-iduronidase (IDUA). Enzyme replacement therapy is recognized as the best therapeutic option for MPSI; however, high titers of anti-IDUA antibody have...

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Main Authors: Martin, Priscila Keiko Matsumoto, Stilhano, Roberta Sessa, Samoto, Vivian Yochiko, Takiya, Christina Maeda, Peres, Giovani Bravin, da Silva Michelacci, Yara Maria Correa, da Silva, Flavia Helena, Pereira, Vanessa Gonçalves, D'Almeida, Vânia, Marques, Fabio Luiz Navarro, Otake, Andreia Hanada, Chammas, Roger, Han, Sang Won
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958533/
https://ncbi.nlm.nih.gov/pubmed/24642723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092420
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