Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBPα growth inhibitory activity

Liver tumor cells arise from normal hepatocytes that escape negative control of proliferation. The transcription factor C/EBPα maintains quiescence of hepatocytes through two pathways: inhibition of cdks and repression of E2F. Nevertheless, liver tumors and cultured hepatoma cell lines proliferate i...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Guo-Li, Iakova, Polina, Wilde, Margie, Awad, Samir, Timchenko, Nikolai A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2004
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC395850/
https://ncbi.nlm.nih.gov/pubmed/15107404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1183304
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