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Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBPα growth inhibitory activity
Liver tumor cells arise from normal hepatocytes that escape negative control of proliferation. The transcription factor C/EBPα maintains quiescence of hepatocytes through two pathways: inhibition of cdks and repression of E2F. Nevertheless, liver tumors and cultured hepatoma cell lines proliferate i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC395850/ https://ncbi.nlm.nih.gov/pubmed/15107404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1183304 |
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