Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBPα growth inhibitory activity

Liver tumor cells arise from normal hepatocytes that escape negative control of proliferation. The transcription factor C/EBPα maintains quiescence of hepatocytes through two pathways: inhibition of cdks and repression of E2F. Nevertheless, liver tumors and cultured hepatoma cell lines proliferate i...

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Publicado en:Genes Dev
Autores principales: Wang, Guo-Li, Iakova, Polina, Wilde, Margie, Awad, Samir, Timchenko, Nikolai A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395850/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15107404/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1183304
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