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Antileishmanial Activity of Semisynthetic Lupane Triterpenoids Betulin and Betulinic Acid Derivatives: Synergistic Effects with Miltefosine

Leishmaniasis is a neglected tropical disease (NTDs), endemic in 88 countries, affecting more than 12 million people. The treatment consists in pentavalent antimony compounds, amphotericin B, pentamidine and miltefosine, among others. However, these current drugs are limited due to their toxicity, d...

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מידע ביבליוגרפי
Main Authors: Sousa, Maria C., Varandas, Raquel, Santos, Rita C., Santos-Rosa, Manuel, Alves, Vera, Salvador, Jorge A. R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958361/
https://ncbi.nlm.nih.gov/pubmed/24643019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089939
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