Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress

Endoplasmic reticulum (ER) stress, caused by the accumulation of unfolded proteins, is involved in the development of obesity. We demonstrated that flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), exhibited chaperone activity, which reduced protein aggregation and alleviated ER stress-in...

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Detalhes bibliográficos
Main Authors: Hosoi, Toru, Yamaguchi, Rie, Noji, Kikuko, Matsuo, Suguru, Baba, Sachiko, Toyoda, Keisuke, Suezawa, Takahiro, Kayano, Takaaki, Tanaka, Shinpei, Ozawa, Koichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958308/
https://ncbi.nlm.nih.gov/pubmed/24421337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303227
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