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erbB3 Is an Active Tyrosine Kinase Capable of Homo- and Heterointeractions
Often considered to be a “dead” kinase, erbB3 is implicated in escape from erbB-targeted cancer therapies. Here, heregulin stimulation is shown to markedly upregulate kinase activity in erbB3 immunoprecipitates. Intact, activated erbB3 phosphorylates tyrosine sites in an exogenous peptide substrate,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3958038/ https://ncbi.nlm.nih.gov/pubmed/24379439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01605-13 |
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