Identification of a Crucial Residue Required for Staphylococcus aureus LukAB Cytotoxicity and Receptor Recognition

The bicomponent leukotoxins produced by Staphylococcus aureus kill host immune cells through osmotic lysis by forming β-barrel pores in the host plasma membrane. The current model for bicomponent pore formation proposes that octameric pores, comprised of two separate secreted polypeptides (S and F s...

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Autors principals: DuMont, Ashley L., Yoong, Pauline, Liu, Xiang, Day, Christopher J., Chumbler, Nicole M., James, David B. A., Alonzo, Francis, Bode, Nadine J., Lacy, D. Borden, Jennings, Michael P., Torres, Victor J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958006/
https://ncbi.nlm.nih.gov/pubmed/24379286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01444-13
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