Toll-Like Receptor 7/8 (TLR7/8) and TLR9 Agonists Cooperate To Enhance HIV-1 Envelope Antibody Responses in Rhesus Macaques

The development of a vaccine that can induce high titers of functional antibodies against HIV-1 remains a high priority. We have developed an adjuvant based on an oil-in-water emulsion that incorporates Toll-like receptor (TLR) ligands to test whether triggering multiple pathogen-associated molecula...

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Hauptverfasser: Moody, M. Anthony, Santra, Sampa, Vandergrift, Nathan A., Sutherland, Laura L., Gurley, Thaddeus C., Drinker, Mark S., Allen, Ashley A., Xia, Shi-Mao, Meyerhoff, R. Ryan, Parks, Robert, Lloyd, Krissey E., Easterhoff, David, Alam, S. Munir, Liao, Hua-Xin, Ward, Brandy M., Ferrari, Guido, Montefiori, David C., Tomaras, Georgia D., Seder, Robert A., Letvin, Norman L., Haynes, Barton F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957956/
https://ncbi.nlm.nih.gov/pubmed/24390332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03309-13
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