HLA-B*57 Elite Suppressor and Chronic Progressor HIV-1 Isolates Replicate Vigorously and Cause CD4(+) T Cell Depletion in Humanized BLT Mice

Elite controllers or suppressors (ES) are HIV-1-infected patients who maintain undetectable viral loads without antiretroviral therapy. The mechanism of control remains unclear, but the HLA-B*57 allele is overrepresented in cohorts of these patients. However, many HLA-B*57 patients develop progressi...

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Bibliographic Details
Main Authors: Salgado, Maria, Swanson, Michael D., Pohlmeyer, Christopher W., Buckheit, Robert W., Wu, Jin, Archin, Nancie M., Williams, Thomas M., Margolis, David M., Siliciano, Robert F., Garcia, J. Victor, Blankson, Joel N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957943/
https://ncbi.nlm.nih.gov/pubmed/24390323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03380-13
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