Core Binding Factor Beta Plays a Critical Role by Facilitating the Assembly of the Vif-Cullin 5 E3 Ubiquitin Ligase

The HIV-1 virion infectivity factor (Vif) targets the cellular cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) for degradation via the host ubiquitin-proteasome pathway. Vif recruits a cellular E3 ubiquitin ligase to polyubiquitinate A3G/F. The activity of Vif critically depends on the cellula...

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Autores principales: Fribourgh, Jennifer L., Nguyen, Henry C., Wolfe, Leslie S., DeWitt, David C., Zhang, Wenyan, Yu, Xiao-Fang, Rhoades, Elizabeth, Xiong, Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957930/
https://ncbi.nlm.nih.gov/pubmed/24390320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03824-13
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