Human Herpesvirus 7 U21 Tetramerizes To Associate with Class I Major Histocompatibility Complex Molecules

The U21 gene product from human herpesvirus 7 binds to and redirects class I major histocompatibility complex (MHC) molecules to a lysosomal compartment. The molecular mechanism by which U21 reroutes class I MHC molecules to lysosomes is not known. Here, we have reconstituted the interaction between...

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Detalhes bibliográficos
Main Authors: May, Nathan A., Wang, Qiuhong, Balbo, Andrea, Konrad, Sheryl L., Buchli, Rico, Hildebrand, William H., Schuck, Peter, Hudson, Amy W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957921/
https://ncbi.nlm.nih.gov/pubmed/24390327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02639-13
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