T-Cell Tolerance for Variability in an HLA Class I-Presented Influenza A Virus Epitope

To escape immune recognition, viruses acquire amino acid substitutions in class I human leukocyte antigen (HLA)-presented cytotoxic T-lymphocyte (CTL) epitopes. Such viral escape mutations may (i) prevent peptide processing, (ii) diminish class I HLA binding, or (iii) alter T-cell recognition. Becau...

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Detalhes bibliográficos
Main Authors: Wahl, Angela, McCoy, William, Schafer, Fredda, Bardet, Wilfried, Buchli, Rico, Fremont, Daved H., Hildebrand, William H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738244/
https://ncbi.nlm.nih.gov/pubmed/19553306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00932-09
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