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Enriching for direct regulatory targets in perturbed gene-expression profiles

Here we build on a previously proposed algorithm to infer direct regulatory relationships using gene-expression profiles from cells in which individual genes are deleted or overexpressed. The updated algorithm can process networks containing feedback loops, incorporate positive and negative regulato...

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Udgivet i:Genome Biol
Principais autores: Tringe, Susannah G, Wagner, Andreas, Ruby, Stephanie W
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2004
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Method
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395788/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15059262/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/gb-2004-5-4-r29
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