Low or High Doses of Cefquinome Targeting Low or High Bacterial Inocula Cure Klebsiella pneumoniae Lung Infections but Differentially Impact the Levels of Antibiotic Resistance in Fecal Flora

The combination of efficacious treatment against bacterial infections and mitigation of antibiotic resistance amplification in gut microbiota is a major challenge for antimicrobial therapy in food-producing animals. In rats, we evaluated the impact of cefquinome, a fourth-generation cephalosporin, o...

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Главные авторы: Vasseur, Maleck V., Laurentie, Michel, Rolland, Jean-Guy, Perrin-Guyomard, Agnès, Henri, Jérôme, Ferran, Aude A., Toutain, Pierre-Louis, Bousquet-Mélou, Alain
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2014
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957826/
https://ncbi.nlm.nih.gov/pubmed/24395228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02135-13
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