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Genetic Redundancy, Proximity, and Functionality of lspA, the Target of Antibiotic TA, in the Myxococcus xanthus Producer Strain
We recently showed that type II signal peptidase (SPaseII) encoded by lspA is the target of an antibiotic called TA (myxovirescin), which is made by Myxococcus xanthus. SPaseII cleaves the signal peptide during bacterial lipoprotein processing. Bacteria typically contain one lspA gene; however, stri...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3957718/ https://ncbi.nlm.nih.gov/pubmed/24391051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01361-13 |
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