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Genetic Redundancy, Proximity, and Functionality of lspA, the Target of Antibiotic TA, in the Myxococcus xanthus Producer Strain

We recently showed that type II signal peptidase (SPaseII) encoded by lspA is the target of an antibiotic called TA (myxovirescin), which is made by Myxococcus xanthus. SPaseII cleaves the signal peptide during bacterial lipoprotein processing. Bacteria typically contain one lspA gene; however, stri...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xiao, Yao, Wall, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957718/
https://ncbi.nlm.nih.gov/pubmed/24391051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01361-13
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