Snail Family Members Unequally Trigger EMT and Thereby Differ in Their Ability to Promote the Neoplastic Transformation of Mammary Epithelial Cells

By fostering cell commitment to the epithelial-to-mesenchymal transition (EMT), SNAIL proteins endow cells with motility, thereby favoring the metastatic spread of tumor cells. Whether the phenotypic change additionally facilitates tumor initiation has never been addressed. Here we demonstrate that...

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Main Authors: Gras, Baptiste, Jacqueroud, Laurent, Wierinckx, Anne, Lamblot, Christelle, Fauvet, Frédérique, Lachuer, Joël, Puisieux, Alain, Ansieau, Stéphane
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956896/
https://ncbi.nlm.nih.gov/pubmed/24638100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092254
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