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Gene Silencing of SOCS3 by siRNA Intranasal Delivery Inhibits Asthma Phenotype in Mice

Suppresors of cytokine signaling (SOCS) proteins regulate cytokine responses and control immune balance. Several studies have confirmed that SOCS3 is increased in asthmatic patients, and SOCS3 expression is correlated with disease severity. The objective of this study was to evaluate if delivering o...

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Detalhes bibliográficos
Main Authors: Mazzeo, Carla, Gámez, Cristina, Rodriguez Marco, Ainara, de Zulueta, Ana, Sanz, Veronica, Bilbao, Izaskun, Ruiz-Cabello, Jesús, Zubeldia, Jose M., del Pozo, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956882/
https://ncbi.nlm.nih.gov/pubmed/24637581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091996
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