Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells

mTOR is an evolutionarily conserved kinase that plays a critical role in sensing and responding to environmental determinants. Recent studies have shown that fine-tuning of the activity of mTOR complexes contributes to organogenesis and tumorigenesis. Although rapamycin, an allosteric mTOR inhibitor...

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Auteurs principaux: Hoshii, Takayuki, Kasada, Atsuo, Hatakeyama, Tomoki, Ohtani, Masashi, Tadokoro, Yuko, Naka, Kazuhito, Ikenoue, Tsuneo, Ikawa, Tomokatsu, Kawamoto, Hiroshi, Fehling, Hans Joerg, Araki, Kimi, Yamamura, Ken-ichi, Matsuda, Satoshi, Hirao, Atsushi
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956177/
https://ncbi.nlm.nih.gov/pubmed/24567410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320265111
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