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Evolutionary history and metabolic insights of ancient mammalian uricases
Uricase is an enzyme involved in purine catabolism and is found in all three domains of life. Curiously, uricase is not functional in some organisms despite its role in converting highly insoluble uric acid into 5-hydroxyisourate. Of particular interest is the observation that apes, including humans...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3956161/ https://ncbi.nlm.nih.gov/pubmed/24550457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320393111 |
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