Evolutionary history and metabolic insights of ancient mammalian uricases

Uricase is an enzyme involved in purine catabolism and is found in all three domains of life. Curiously, uricase is not functional in some organisms despite its role in converting highly insoluble uric acid into 5-hydroxyisourate. Of particular interest is the observation that apes, including humans...

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Detaylı Bibliyografya
Asıl Yazarlar: Kratzer, James T., Lanaspa, Miguel A., Murphy, Michael N., Cicerchi, Christina, Graves, Christina L., Tipton, Peter A., Ortlund, Eric A., Johnson, Richard J., Gaucher, Eric A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956161/
https://ncbi.nlm.nih.gov/pubmed/24550457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320393111
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