Central Nervous System Delivery of Helper-Dependent Canine Adenovirus Corrects Neuropathology and Behavior in Mucopolysaccharidosis Type VII Mice

Canine adenovirus type 2 vectors (CAV-2) are promising tools to treat global central nervous system (CNS) disorders because of their preferential transduction of neurons and efficient retrograde axonal transport. Here we tested the potential of a helper-dependent CAV-2 vector expressing β-glucuronid...

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Autors principals: Ariza, Lorena, Giménez-Llort, Lydia, Cubizolle, Aurélie, Pagès, Gemma, García-Lareu, Belén, Serratrice, Nicolas, Cots, Dan, Thwaite, Rosemary, Chillón, Miguel, Kremer, Eric J., Bosch, Assumpció
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955973/
https://ncbi.nlm.nih.gov/pubmed/24299455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.152
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