Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1

The homeostasis of insulin-like growth factor-1 (IGF-1) is essential for metabolism, development and survival. Insufficient IGF-1 is associated with poor recovery from wounds whereas excessive IGF-1 contributes to growth of tumours. We have shown that cyclic glycine-proline (cGP), a metabolite of IG...

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Main Authors: Guan, Jian, Gluckman, Peter, Yang, Panzao, Krissansen, Geoff, Sun, Xueying, Zhou, Yongzhi, Wen, Jingyuan, Phillips, Gemma, Shorten, Paul R., McMahon, Chris D., Wake, Graeme C., Chan, Wendy H. K., Thomas, Mark F., Ren, April, Moon, Steve, Liu, Dong-Xu
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955921/
https://ncbi.nlm.nih.gov/pubmed/24633053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04388
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