A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells.

The Philadelphia translocation commonly observed in chronic myeloid leukaemia (CML) and a proportion of cases of acute leukaemia results in the creation of a chimeric fusion protein, BCR-ABL. The fusion protein exhibits an elevated tyrosine kinase activity as compared to normal ABL. Using a temperat...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Kabarowski, J H, Allen, P B, Wiedemann, L M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395564/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7813429/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06934.x
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