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Polyketide Construction via Hydrohydroxyalkylation and Related Alcohol C-H Functionalizations: Reinventing the Chemistry of Carbonyl Addition

Despite the longstanding importance of polyketide natural products in human medicine, nearly all commercial polyketide-based drugs are prepared through fermentation or semi-synthesis. The paucity of manufacturing routes involving de novo chemical synthesis reflects the inability of current methods t...

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Библиографические подробности
Главные авторы: Dechert-Schmitt, Anne-Marie R., Schmitt, Daniel C., Gao, Xin, Itoh, Takahiko, Krische, Michael J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954971/
https://ncbi.nlm.nih.gov/pubmed/24514754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3np70076c
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