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Polyketide Construction via Hydrohydroxyalkylation and Related Alcohol C-H Functionalizations: Reinventing the Chemistry of Carbonyl Addition
Despite the longstanding importance of polyketide natural products in human medicine, nearly all commercial polyketide-based drugs are prepared through fermentation or semi-synthesis. The paucity of manufacturing routes involving de novo chemical synthesis reflects the inability of current methods t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3954971/ https://ncbi.nlm.nih.gov/pubmed/24514754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3np70076c |
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