Loss of CD11b Exacerbates Murine Complement-Mediated Tubulointerstitial Nephritis

Acute complement activation occurs in the tubulointerstitium (TI) of kidneys transplanted from Crry(−/−)C3(−/−) mice into complement-sufficient wildtype mice, followed by marked inflammatory cell infiltration, tubular damage and interstitial fibrosis. We postulated iC3b-CD11b interactions were criti...

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Main Authors: Chaves, Lee Daniel, Bao, Lihua, Wang, Ying, Chang, Anthony, Haas, Mark, Quigg, Richard John
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954915/
https://ncbi.nlm.nih.gov/pubmed/24632830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092051
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