Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.

The beta subunit (beta c) of the receptors for human granulocyte macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5) is essential for high affinity ligand-binding and signal transduction. An important feature of this subunit is its common nature, being able t...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Woodcock, J M, Zacharakis, B, Plaetinck, G, Bagley, C J, Qiyu, S, Hercus, T R, Tavernier, J, Lopez, A F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395466/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7957082/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06848.x
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