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MicroRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites

Dihydropyrimidine dehydrogenase (DPD, encoded by DPYD) is the rate-limiting enzyme in the uracil catabolic pathway and has a pivotal role in the pharmacokinetics of the commonly prescribed anti-cancer drug 5-fluorouracil (5-FU). Deficiency of DPD, whether due to inadequate expression or deleterious...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Offer, Steven M., Butterfield, Gabriel L., Jerde, Calvin R., Fossum, Croix C., Wegner, Natalie J., Diasio, Robert B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954441/
https://ncbi.nlm.nih.gov/pubmed/24401318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0878
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