Histone Deacetylase Inhibitor Impairs Plasminogen Activator Inhibitor-1 Expression via Inhibiting TNF-α-Activated MAPK/AP-1 Signaling Cascade

Tumor necrosis factor-(TNF-)-α upregulates plasminogen activator inhibitor-(PAI-) 1 expression in pleural mesothelial cells (PMCs), contributing to fibrin deposition and pleural fibrosis. Histone deacetylases (HDACs) have been found implicated in fibrogenesis. However, the roles of TNF-α or HDAC in...

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Detalhes bibliográficos
Main Authors: Chen, Wei-Lin, Sheu, Joen-Rong, Hsiao, Che-Jen, Hsiao, Shih-Hsin, Chung, Chi-Li, Hsiao, George
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953480/
https://ncbi.nlm.nih.gov/pubmed/24707477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/231012
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