An asymmetric nucleotide in the parvoviral 3' hairpin directs segregation of a single active origin of DNA replication.

The 3' telomere of the linear single-stranded DNA genome of minute virus of mice (MVM), a murine parvovirus, can assume a complex hairpin structure. This contains a stem in which there is a mismatched 'bubble' sequence where a GA doublet opposes a GAA triplet. During replication, this...

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Bibliographic Details
Main Authors: Cotmore, S F, Tattersall, P
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC395337/
https://ncbi.nlm.nih.gov/pubmed/8076610
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