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A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

Steroid receptors activate and repress genes. An important class of genes that they repress is controlled by the transcription factor AP-1. The activity of AP-1 is inhibited by the receptor, a mechanism exploited for the therapy of various forms of pathological hyperproliferation in humans. We show...

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Udgivet i:EMBO J
Principais autores: Heck, S, Kullmann, M, Gast, A, Ponta, H, Rahmsdorf, H J, Herrlich, P, Cato, A C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395330/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8076604/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06726.x
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