Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria

Mitochondrial iron is essential for the biosynthesis of heme and iron-sulfur ([Fe-S]) clusters in mammalian cells. In developing erythrocytes, iron is imported into the mitochondria by MFRN1 (mitoferrin-1, SLC25A37). Although loss of MFRN1 in zebrafish and mice leads to profound anemia, mutant anima...

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Bibliografiset tiedot
Päätekijät: Chung, Jacky, Anderson, Sheila A., Gwynn, Babette, Deck, Kathryn M., Chen, Michael J., Langer, Nathaniel B., Shaw, George C., Huston, Nicholas C., Boyer, Leah F., Datta, Sumon, Paradkar, Prasad N., Li, Liangtao, Wei, Zong, Lambert, Amy J., Sahr, Kenneth, Wittig, Johannes G., Chen, Wen, Lu, Wange, Galy, Bruno, Schlaeger, Thorsten M., Hentze, Matthias W., Ward, Diane M., Kaplan, Jerry, Eisenstein, Richard S., Peters, Luanne L., Paw, Barry H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2014
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953295/
https://ncbi.nlm.nih.gov/pubmed/24509859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.547778
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