Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria

Mitochondrial iron is essential for the biosynthesis of heme and iron-sulfur ([Fe-S]) clusters in mammalian cells. In developing erythrocytes, iron is imported into the mitochondria by MFRN1 (mitoferrin-1, SLC25A37). Although loss of MFRN1 in zebrafish and mice leads to profound anemia, mutant anima...

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Detalhes bibliográficos
Main Authors: Chung, Jacky, Anderson, Sheila A., Gwynn, Babette, Deck, Kathryn M., Chen, Michael J., Langer, Nathaniel B., Shaw, George C., Huston, Nicholas C., Boyer, Leah F., Datta, Sumon, Paradkar, Prasad N., Li, Liangtao, Wei, Zong, Lambert, Amy J., Sahr, Kenneth, Wittig, Johannes G., Chen, Wen, Lu, Wange, Galy, Bruno, Schlaeger, Thorsten M., Hentze, Matthias W., Ward, Diane M., Kaplan, Jerry, Eisenstein, Richard S., Peters, Luanne L., Paw, Barry H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953295/
https://ncbi.nlm.nih.gov/pubmed/24509859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.547778
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