Crystal Structure of a Schistosoma mansoni Septin Reveals the Phenomenon of Strand Slippage in Septins Dependent on the Nature of the Bound Nucleotide

Septins are filament-forming GTP-binding proteins involved in important cellular events, such as cytokinesis, barrier formation, and membrane remodeling. Here, we present two crystal structures of the GTPase domain of a Schistosoma mansoni septin (SmSEPT10), one bound to GDP and the other to GTP. Th...

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Autori principali: Zeraik, Ana E., Pereira, Humberto M., Santos, Yuri V., Brandão-Neto, José, Spoerner, Michael, Santos, Maiara S., Colnago, Luiz A., Garratt, Richard C., Araújo, Ana P. U., DeMarco, Ricardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953292/
https://ncbi.nlm.nih.gov/pubmed/24464615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.525352
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