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The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner

Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of growth and metabolism. We find that either loss or gain of function of Drosophi...

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Detalhes bibliográficos
Main Authors: Galagovsky, Diego, Katz, Maximiliano J., Acevedo, Julieta M., Sorianello, Eleonora, Glavic, Alvaro, Wappner, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952859/
https://ncbi.nlm.nih.gov/pubmed/24430872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-04-0213
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