High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade

Cutaneous T-cell lymphomas (CTCLs) are malignancies of skin-homing lymphoid cells, which have so far not been investigated thoroughly for common oncogenic mutations. We screened 90 biopsy specimens from CTCL patients (41 mycosis fungoides, 36 Sézary syndrome, and 13 non–mycosis fungoides/Sézary synd...

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Detaylı Bibliyografya
Asıl Yazarlar: Kießling, Michael K., Oberholzer, Patrick A., Mondal, Chandrani, Karpova, Maria B., Zipser, Marie C., Lin, William M., Girardi, Michael, MacConaill, Laura E., Kehoe, Sarah M., Hatton, Charlie, French, Lars E., Garraway, Levi A., Polier, Gernot, Süss, Dorothee, Klemke, Claus-Detlev, Krammer, Peter H., Gülow, Karsten, Dummer, Reinhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2011
Konular:
Lymphoid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952811/
https://ncbi.nlm.nih.gov/pubmed/21209378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-305128
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